在日本队列中,针对完整血清参数的妊娠特定参考间隔
Kanatsu Kawakami1, Shimokawa Risa1, Fumitaka Saito1
1Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto City, Kumamoto, Japan.
The journal of obstetrics and gynaecology research
|July 21, 2025
概括
这项研究建立了日本怀孕的妊娠年龄特定的全血细胞计 (CBC) 参考间隔. 母亲的BMI和年龄显著影响CBC参数,这对于准确的产前血液学评估至关重要.
科学领域:
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
- 人口健康 人口健康
背景情况:
- 在怀孕期间,全血细胞计 (CBC) 参数发生显著变化.
- 确定准确的参考间隔对于监测母亲和胎儿健康至关重要.
- 现有的CBC参考间隔可能不能充分代表日本孕妇等多样化的人口.
研究的目的:
- 在日本人口中确定八个CBC参数的妊娠年龄特定参考间隔.
- 调查母亲的体重指数 (BMI) 和母亲的年龄对这些CBC参数的影响.
- 为产前护理提供最新的血液学评估指南.
主要方法:
- 在一个机构对33355例单独怀孕的回顾性队列研究.
- 分析了八个CBC参数:WBC,RBC,Hb,Ht,MCV,MCH,MCHC和PLT. 这些参数包括:WBC,RBC,Hb,Ht,MCV,MCH,MCHC和PLT.
- 在三个妊娠期内确定2.5至97.5百分点的参考间隔,并使用ANOVA评估BMI/年龄的影响.
主要成果:
- 为CBC参数建立了妊娠年龄特定的参考间隔.
- 在整个怀孕期间确定了WBC,RBC,Hb,Ht,MCV,MCH,MCHC和PLT的不同变化模式.
- 在较高的母亲BMI和高的WBC,RBC,Hb,Ht和PLT之间有显著的关联;母亲的年龄与WBC,MCV和MCH变异相关.
结论:
- 这项研究为怀孕期间的CBC提供了必要的,人群特定的参考间隔.
- 孕妇的BMI和年龄是解释怀孕期间CBC结果的关键因素.
- 这些发现强调了需要考虑母亲的个体特征来进行精确的产前血液学评估的必要性.
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