生物相容NaLn(WO4) 2核心外纳米血小板用于多模式MRI对比,NIR成像和高灵敏度红外发光比度温度计
Carlos Alarcón-Fernández1, Carlos Zaldo1, Manuel Bañobre-López2
1Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain. ccascales@icmm.csic.es.
Journal of materials chemistry. B
|July 21, 2025
概括
研究人员开发了新的多功能纳米探针,用于先进的医学成像. 这些纳米探测器提供了磁共振成像 (MRI) 对比,近红外 (NIR) 成像和精确的温度测量功能,用于增强诊断.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 开发用于同时成像和传感的多功能纳米探针对于先进的诊断至关重要.
- 现有的纳米探测器往往缺乏整合多种模式,如MRI,NIR成像和温度计.
- 类似于Scheelite的NaLn(WO4) 2宿主材料提供了创造具有定制性质的新型纳米结构的潜力.
研究的目的:
- 为了展示多功能纳米探针,将MRI对比度,NIR成像和温度计结合起来.
- 为了研究基于NaLn的近二维核心-多纳米结构的性能.
- 为了评估纳米探测器在不同磁场强度和生物条件下的能力.
主要方法:
- 核心-多纳米结构与NaHo(WO4) 2核心和Tm,Yb:NaGd(WO4) 2/Nd,Yb:NaGd(WO4) 2外的合成.
- 质子核磁放松分散研究和MRI在1.5T,3T和7T.
- 在第二个生物透明度窗口 (II-BW) 中使用Nd3+和Yb3+排放的近红外 (NIR) 激发Nd3+用于基于发光的温度计.
主要成果:
- 纳米探针显示可调节的MRI对比度 (T1加权在1.5T,T2加权在7T,双T1/T2在3T).
- 发光温度计实现了高灵敏度 (SA = 480 × 10-4 K-1,SR = 0.89% K-1在40 °C) 和分辨率 (δ ≈ 0.1 K).
- 通过Tm3+和Ho3+排放,高效的能量转移使深层组织NIR光发光成像成为可能.
结论:
- 准二维核心多NaLn(WO4) 2纳米结构是有效的多功能探针.
- 这些纳米探测器提供了多功能MRI对比度,精确的发光温度测量和深层组织成像能力.
- 低细胞毒性支持它们在体内应用的潜力,包括细胞温度测量.
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