[通过牛奶加工的Euphorbiae Ebracteolatae Radix减少肠道毒性的机制]
Chang-Li Shen1, Hao Wu2, Hong-Li Yu2
1School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
概括
牛奶加工显著降低了Euphorbiae Ebracteolatae Radix的肠道毒性和净化作用,因为它将有毒的类化合物与素小粒结合. 这项研究揭示了中国传统医学的新型解毒机制.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 传统中国医药 传统中国医药
背景情况:
- 欧虫 Ebracteolatae Radix (Langdu) 具有清洁性,但与显著的肠道毒性有关.
- 传统的加工方法,如牛奶,用于减轻草药的毒性.
- 对于Euphorbiae Ebracteolatae Radix的牛奶加工的特定排毒机制仍然不完全理解.
研究的目的:
- 为了研究肠道毒性变化和牛奶加工后Euphorbiae Ebracteolatae Radix的化学组成之间的相关性.
- 在Euphorbiae Ebracteolatae Radix.上探索牛奶加工的排毒机制.
- 评估牛奶加工对Euphorbiae Ebracteolatae Radix.的清洁效应和炎症毒性的影响.
主要方法:
- 动物模型 (老鼠) 使用原料,奶制成和水制成的Euphorbiae Ebracteolatae Radix提取物.
- 使用体形态,水含量和炎症性细胞因子水平 (TNF-α,IL-1β) 评估肠道毒性.
- 化学分析使用LC-MS/MS来识别和量化成分,以及TEM,粒子大小分析和光谱学来研究牛奶蛋白和草本成分之间的相互作用.
主要成果:
- 与原始或经过水处理的牛奶相比,牛奶加工显著降低了肠道毒性和炎症的指标.
- LC-MS/MS分析显示,牛奶加工后有毒的类成分减少,许多在牛奶沉物中被发现.
- 光谱和显微镜分析证实了牛奶素小粒和有毒类物之间的相互作用,导致小粒重组和组件的封存.
结论:
- 牛奶加工有效地降低了Euphorbiae Ebracteolatae Radix的肠道炎症毒性和净化作用.
- 排毒机制涉及有毒的类成分与牛奶素小粒的相互作用和重组,促进它们的去除.
- 牛奶加工是一种有价值的辅助方法,用于排毒Euphorbiae Ebracteolatae Radix,提高其药用安全性.
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