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[通过UHPLC-Q-TOF-MS方法快速表征和识别Rhododendron tomentosum中的非挥发性成分]

Su-Ping Xiao¹, Long-Mei Li², Bin Xie²

¹School of Pharmaceutical Sciences, Peking University Beijing 100871, China China National Traditional Chinese Medicine Co., Ltd. Beijing 100195, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|July 21, 2025

概括

这项研究使用UHPLC-Q-TOF-MS识别了Rhododendron tomentosum提取物中的118种非挥发性化合物.最近报告了100多种化合物,为R. tomentosum的研究和开发提供了洞察力.

科学领域:

植物化学植物化学
分析化学分析化学
药理学是指药理学,即药理学是指药理学.

背景情况:

rhododendron tomentosum (R. tomentosum) 是一种具有传统药用用途的植物.
缺乏对其化学成分的全面描述.

研究的目的:

系统地识别和描述R. tomentosum茎和叶子的水和乙醇提取物中的非挥发性化学成分.
为进一步研究R. tomentosum的活性成分,质量控制和产品开发奠定基础.

主要方法:

超高性能液态染色学-四极时飞行质谱学 (UHPLC-Q-TOF-MS) 用于敏感和高效的分析.
用自建的信息数据库,与参考化合物进行比较,碎片离子分析和文献搜索来识别化合物.

主要成果:

总共有118种非挥发性化合物被识别出来,包括黄类糖化物,类糖化物,黄类,酸等.
其中102种已识别的化合物首次在R. tomentosum中报告.
在乙醇和水性提取物之间观察到化学特征的微小变化,其中有84种常见化合物.

结论:

这项研究提供了R. tomentosum提取物中非挥发性成分的第一个系统性表征.
鉴定的化合物和分析方法作为未来研究,质量控制和开发基于R. tomentosum的产品的宝贵参考.

关键词:

罗多树的体积 (tomenosum)在UHPLC-Q-TOF-MS中使用.这种类型的黄类药物是flavonoid.黄类葡萄糖化物 (Flavonoid Glycoside) 是一种分裂模式的碎片化模式.类葡萄糖化物类葡萄糖化物类葡萄糖化物

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