动态肠道:脊椎动物的胃肠道和相关的微生物群表现出生理灵活性和适应饮食的适应性
William H Karasov1, Kevin D Kohl2, Enrique Caviedes-Vidal1,3,4
1Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI 53706, USA.
The Journal of experimental biology
|July 21, 2025
概括
适应性消化假设 (ADH) 表明,消化酶与食基质相匹配,以节省能量. 来自基因组学和脊椎动物之间的比较研究的证据支持这一点,显示消化系统适应饮食.
科学领域:
- 进化生物学 进化生物学
- 生理生态生态学 生理生态学
- 分子生物学分子生物学
背景情况:
- 适应性消化假设 (ADH) 假设消化酶和输送物水平与饮食基质的可用性保持一致.
- 这种对齐可以防止在低丰度基质的分子机械上浪费能量.
研究的目的:
- 审查支持适应性消化假设 (ADH) 的证据.
- 探索脊椎动物及其微生物群的消化适应背后的分子和细胞机制.
主要方法:
- 对基因组,转录组和功能研究的审查.
- 跨多种脊椎动物分类 (哺乳动物,鸟类,鱼类) 的比较分析,具有多样化的饮食.
- 检查脊椎动物微生物组及其功能转移.
主要成果:
- 基因组和功能数据通常支持ADH,特别是在向高粉饮食的进化过渡中.
- 在各种脊椎动物中进行的比较研究表明,消化酶/输送活性与饮食专业化相匹配.
- 脊椎动物微生物组显示出显著的分类学和功能适应宿主饮食.
- 杂食动物在与热量基质相关的消化酶活性中表现出类型的可塑性.
结论:
- ADH在脊椎动物进化和饮食专业化方面的证据广泛支持.
- 消化适应涉及宿主及其微生物群的复杂分子和细胞调节.
- 需要进一步的研究,以阐明酶和输送器调节的精确协调.
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