在大肠炎期间,ATP在肠粘膜系统中调解热
Sihyun Jeong1, Soyeong Park1, Doyeon Lee1
1Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Journal of cellular physiology
|July 21, 2025
概括
细胞外ATP作为损伤相关的分子模式 (DAMP) 在结肠炎期间触发肠上皮细胞中的热致死. 升高的ATP水平促进炎症和细胞死亡,加剧了这种情况.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 细胞生物学 细胞生物学
背景情况:
- 与损伤相关的分子模式 (DAMPs) 被应激细胞释放,促进炎症.
- 细胞外ATP是一种DAMP,主要研究在单细胞中,但其在肠道中的作用不太清楚.
研究的目的:
- 为了研究细胞外ATP作为DAMP在诱导肠道粘膜系统内热的作用.
- 在大肠炎的小鼠模型中分析ATP水平和热致死媒介.
主要方法:
- 在使用德克斯硫酸盐的小鼠中诱导大肠炎.
- 在结肠组织和血清中测量了ATP水平和与热相关的蛋白质表达.
- 在体外用ATP治疗结肠上皮细胞,以评估细胞死亡和热.
主要成果:
- 大肠炎小鼠在结肠和血清中显示ATP水平增加.
- 在大肠炎小鼠的结肠中,质中介物被显著上调.
- 在体外ATP治疗诱导了细胞死亡,线粒体功能障碍和结肠上皮细胞中的亡,但不是亡.
结论:
- 细胞外ATP充当DAMP,在结肠炎期间诱导肠上皮细胞中的热致死.
- 升高的ATP水平有助于自扩散的火死循环,恶化肠道炎症.
- 这项研究扩大了对以ATP为媒介的热的理解,将其应用于肠道环境.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.4K
06:31Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
Published on: June 2, 2023
1.1K
相关概念视频
Allosteric Proteins-ATCase
5.9K
Binding sites linkages can regulate a protein's function. For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
5.9K
Phagocytosis of Apoptotic Cells
4.0K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
4.0K
Gastritis-II: Pathophysiology
558
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
558
Translocation of Proteins into the Mitochondria
3.3K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
3.3K
