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适应性反应:对其在医学,太空探索和其他领域的影响进行全面审查

Abolfazl Kanani^1,2, Julianna Krasowska³, Krzysztof W Fornalski³

¹Pardis Cancer Research Center, Pardis Cancer Institute, Shiraz, Iran.

Dose-response : a publication of International Hormesis Society

|July 21, 2025

概括

辐射适应反应 (AR),由低剂量辐射 (LDR) 触发,增强对更高剂量的弹性. 本综述探讨了AR的研究.

科学领域:

辐射生物学辐射生物学
细胞和分子机制的机制
翻译医学是一种翻译医学.

背景情况:

适应性反应 (AR) 是一种现象,低剂量辐射 (LDR) 暴露提高了对随后更高剂量的耐药性.
AR在各种领域都有影响,包括瘤学,神经退行性疾病,太空医学和流行病应对.
了解AR的机制对于利用其保护潜力至关重要.

研究的目的:

进行关于辐射适应反应 (AR) 的实验和临床研究的综合范围审查.
总结关于AR分子机制,生物效应和生物物理建模的证据.
评估AR在各种医疗和空间相关领域的翻译应用.

主要方法:

关于辐射适应反应 (AR) 的实验和临床研究的综合性综述.
专注于分子机制,生物影响,生物物理建模和翻译应用.
范围审查方法,以确定证据,研究缺口和潜在的应用.

主要成果:

在放射治疗期间,AR显示出保护正常组织的承诺,同时使瘤细胞敏感,尽管效果取决于细胞类型.
低剂量辐射 (LDR) 可能通过调节氧化应激和炎症来帮助管理神经退行性疾病.
基于AR的宇航员选择被提议用于太空任务,但缺乏经验验证;COVID-19的LDR存在道德问题.

结论:

临床和太空飞行AR的实施需要进一步的机制理解,标准化的协议和严格的研究.
诸如瘤发生,个体变异性和免疫调节效应等风险在AR应用之前需要进行彻底评估.
不一致的AR现象使其研究和临床实用性复杂化,需要进一步研究.

关键词:

在 COVID-19 疫情中,适应性反应是一种适应性反应.癌症治疗疗法癌症治疗低剂量的低剂量空间空间空间空间空间的空间.

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