相关实验视频

Updated: Sep 14, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

在未接受过治疗的和接受过甲状腺素治疗的类风湿性关节炎患者中的IL-40水平

Hamdi Oğuzman¹, Mete Pekdiker²

¹Department of Medical Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.

Turkish journal of medical sciences

|July 21, 2025

概括

在类风湿性关节炎 (RA) 患者中,介素-40 (IL-40) 水平升高,表明它在疾病中的潜在作用. 这些升高的IL-40水平即使在甲状腺素治疗中也会持续存在,这表明它参与了反应较弱的免疫路径.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种自身免疫性疾病,导致关节炎症和损伤.
介素-40 (IL-40) 是一种新发现的细胞因子,在RA的发病过程中起到尚未探索的作用.

研究的目的:

研究IL-40在类风湿性关节炎 (RA) 中的作用.
在RA患者中研究IL-40和其他细胞因子 (IL-4,TGF-β1,TNF-α) 之间的关系.

主要方法:

一项涉及87名参与者的横截面研究:29名健康对照组,29名新诊断的RA患者和29名接受甲醇 (MTX) 单疗法的RA患者.
使用ELISA测量IL-40,IL-4,TGF-β1和TNF-α的血清水平.
收集了临床数据,包括疾病活性和自身抗体.

主要成果:

与对照组相比,IL-40水平在新诊断的RA患者和接受MTX治疗的患者中显著升高 (p < 0.001).
IL-40被确定为新诊断和MTX治疗的RA患者的独立预测因子.
根据血清阳性,TGF-β1和TNF-α水平在MTX治疗的患者与未接受治疗的患者之间显示出差异性变化.

结论:

在RA患者中存在高IL-40水平,这表明它在疾病中起着重要作用.
尽管接受了MTX治疗,但IL-40水平仍然很高,这表明它参与了可能对当前疗法的免疫路径的反应较低.

关键词:

介质蛋白-40 介质蛋白-40 细胞因子细胞因子介质蛋白-4 介质蛋白-4 甲基特雷克萨酸盐的使用方法转化生长因子β-1的转化生长因子β-1 瘤亡因子-阿尔法

更多相关视频

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

相关概念视频

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...