基本的饮食微量元素的关联及其与认知的混合:一个前性研究
Huihui Li1, Zhongmin Yin2, Fusheng Cui1
1Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, China.
Frontiers in nutrition
|July 21, 2025
概括
铁和等饮食中必需的微量元素 (ETE) 与认知有非线性联系. 摄入水平很重要,对和观察到的性别差异.
科学领域:
- 营养神经科学 营养神经科学
- 认知功能的生物标志物
- 公共卫生 营养 公共卫生 营养
背景情况:
- 饮食中必需的微量元素 (ETE) 与认知功能之间的关系尚未完全理解.
- 铁 (Fe),铜 (Cu), (Zn), (Mn), (Se) 和 (I) 等ETE对大脑健康至关重要.
研究的目的:
- 研究个人和混合饮食ETE与一般认知之间的关联.
- 为了确定潜在的非线性关系和最佳摄入水平对ETE有关认知.
主要方法:
- 利用来自英国生物银行 (UKB) 的前性队列数据.
- 采用线性回归,受限立方线 (RCS) 和贝叶斯内核机器回归 (BKMR) 模型.
- 进行分层和敏感性分析,以确保调查结果的可靠性.
主要成果:
- 确定了个别ETE (Fe,Zn,Cu,I,Mn,Se) 与一般认知之间显著的非线性关联.
- BKMR分析显示ETE混合物的反转"U"形曲线,其中Fe和Zn是主要贡献者.
- 观察到的性别差异:Mn在男性中占主导地位,Zn在女性中占主导地位;Zn和Mn在高血压患者中显著.
结论:
- 饮食中摄入的Fe,Zn,Cu,I,Mn和Se,无论是单独的还是混合的,都表现出与一般认知的非线性关联.
- 铁和在ETE混合物对认知的影响中起着关键作用.
- 外星生物的认知贡献因性别而异,和在男性和女性中特别有影响.
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