相关实验视频

Updated: Sep 14, 2025

Single Particle Cryo-Electron Microscopy: From Sample to Structure
11:52

Single Particle Cryo-Electron Microscopy: From Sample to Structure

Published on: May 29, 2021

8.8K

UM-CPP:一种通用模型,用于高效地对蛋白质颗粒进行分类,用于具有特征工程功能的冷电磁显微镜.

Zhaomin Yao1,2, Hongyu Wang1,2, Wenxuan Luo2

  • 1Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, China.

ACS omega
|July 21, 2025
PubMed
概括

一个新的冷电子显微镜粒子采集通用模型 (UM-CPP) 增强了冷电子显微镜 (cryo-EM) 数据中的粒子检测. 这种先进的框架提高了生物大分子的结构研究的准确性和解释性.

更多相关视频

Cryo-EM and Single-Particle Analysis with Scipion09:06

Cryo-EM and Single-Particle Analysis with Scipion

Published on: May 29, 2021

3.9K
A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion13:43

A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion

Published on: January 31, 2022

13.9K

相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
3.6K
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.5K