步行和平衡功能障碍仅在患有帕金森病的男性中与认知表现有关
Amy W Amara1, Kimberly H Wood2,3,4,5, Aya M Miften1
1Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Clinical parkinsonism & related disorders
|July 21, 2025
概括
帕金森病 (PD) 的认知功能与平衡,步态和移动性有关,特别是在男性中. 这些运动功能与男性PD患者的认知表现有显著的相关性,但女性没有.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 认知神经科学 认知神经科学
背景情况:
- 帕金森病 (PD) 的特点是运动和认知障碍.
- 运动器官功能障碍 (行走,平衡,移动性) 和认知能力下降在PD患者中经常同时发生.
- 了解认知功能和运动性能之间的关系对于管理PD至关重要.
研究的目的:
- 研究帕金森病患者的综合认知表现与特定运动功能领域之间的关联.
- 在患有PD的男性和女性中分别检查这些关系.
主要方法:
- 招募了60名患有PD的参与者 (Hoehn和Yahr阶段1-3,年龄≥45,MoCA分数≥18).
- 使用定时启动和启动 (TUG),最大步行速度 (MWS) 和迷你平衡评估系统测试 (Mini-BESTest) 评估了运动机动功能.
- 从综合的神经认知电池中得出一个认知复合得分 (CCS);斯皮尔曼相关性分析了关联.
主要成果:
- 认知综合评分 (CCS) 与PD整体组和男性中的所有主要运动器结果有显著的相关性.
- 在整体组和男性中发现了CCS和平衡 (Mini-BESTest) 和步态 (MWS) 之间的正相关性.
- 在整体组和男性中观察到CCS和移动性 (TUG) 之间的负相关性;在女性中没有发现显著的相关性.
结论:
- 全球认知功能与帕金森病中的平衡,步态和移动性有关.
- 运动功能和认知表现之间的相关性仅在患有PD的男性中显著.
- 这项研究突出了PD认知和运动领域之间的复杂关系,观察到性别特异性差异.
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