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氨基糖化物对比β-乳酸治疗尿道症 - - 一个回顾性队列研究
Amos Cahan1,2, Roy Peleg2, Nadav Sorek3
1Infectious Diseases Unit, Samson Assuta Ashdod University Hospital, Harefua St. 7, Ashdod 7747629, Israel.
JAC-antimicrobial resistance
|July 21, 2025
概括
氨基糖化物在治疗格兰阴性细菌性尿路感染 (UTI) 方面表现出与β-乳糖类药物相似的疗效. 这些发现表明,氨基糖化物可能是尿路感染的可行第一线选择.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 由ESBL产生的肠杆菌引起的尿路感染 (UTI) 正在增加.
- 氨基糖化物在尿路感染治疗方面越来越受到关注,但与β-乳糖胺 (BLs) 的比较数据有限.
研究的目的:
- 为了比较aminoglycoside与BL单疗的疗效和安全性,在患有格兰阴性细菌性尿路感染的患者中.
- 为了评估两个治疗组之间的临床改善,死亡率和损伤率.
主要方法:
- 对134名患有格兰阴性细菌性尿路感染的患者进行了回顾性队列研究.
- 患者至少接受了3天的aminoglycoside或BL单疗法.
- 主要结局:在72小时内临床改善;次要结局:通过出院的临床改善,改善的时间,死亡率,停留时间,复发和损伤.
主要成果:
- 在72小时 (65.8%对55%) 和放出 (94.7%对87.5%) 的临床改善率在氨基糖化物和BL组之间是相似的.
- 多变量分析证实了类似的疗效 (OR 1.52对于BLs与氨基糖化物).
- 氨基糖化物组的住院时间较短 (1.7天),其他二次结果或损伤没有显著差异.
结论:
- 氨基糖化物在治疗格拉姆阴性细菌性尿路感染方面,其疗效和安全性与BLs相当.
- 考虑到它们的广泛活性和药理动力学,氨基糖化物值得考虑作为一线尿路感染治疗选择.
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