在患有胸部瘤的老年患者中,放射治疗前的脆弱性和相关决定因素
Xiaoying Shen1, Xiaofang Qi1, Xiaowei Fu1
1Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
Translational cancer research
|July 21, 2025
概括
患有胸部瘤的老年患者往往会经历虚弱,受年龄,健康状况和生活方式的影响. 早期评估和干预对于管理这一群体的脆弱性至关重要.
科学领域:
- 老年瘤学 老年瘤学
- 放射治疗研究 放射治疗研究
- 虚弱综合症 (Frailty Syndromes) 是一种虚弱的综合症.
背景情况:
- 患有胸部瘤 (肺,食道,中) 的老年患者因与年龄相关的脆弱性而面临独特的放射治疗 (RT) 挑战.
- 影响RT结果的因素包括年龄,并发症,多种药物,体力活动,白蛋白水平,心理困扰和睡眠障碍.
研究的目的:
- 为管理和干预乳的老年患者接受胸部瘤放射治疗提供参考.
- 确定导致这种脆弱患者群体在放射治疗前虚弱的关键因素.
主要方法:
- 使用了Tilburg脆弱性指数,一般信息问卷和口腔脆弱性查量表的中文版本.
- 评估了139名60岁以上的患者,计划接受胸部瘤放射治疗.
- 采用多重线性回归分析来确定影响RT前脆弱性的因素.
主要成果:
- 28.1%的患有胸部瘤的老年患者在RT前被归类为脆弱.
- 整体脆弱性得分为3.75±2.429,有显著的社会 (1.56±0.772) 和口腔 (3.38±1.987) 脆弱性组成部分.
- 关键影响因素包括晚年,并发病,多种药物,运动类型/持续时间,低白蛋白,心理困扰和睡眠障碍.
结论:
- 患有胸部瘤的老年患者在身体,社会,心理和口腔领域表现出显著的脆弱性.
- 易受脆弱性的加剧了老年,多种并发病,多药,有限的阻力运动,和低白蛋白.
- 优先考虑脆弱性评估和及时实施全面干预措施对于缓解这些患者脆弱性进展至关重要.
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