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在患有pT1结直肠癌的患者中,淋巴结转移的分支

Liming Wang^1,2, Pengchen Long^1,3, Yinggang Chen¹

¹Department of Gastrointestinal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Translational cancer research

|July 21, 2025

概括

淋巴结转移 (LNM) 在手术后对pT1N1期结直肠癌 (CRC) 患者的长期存活没有影响. 这表明pT1N1 CRC可能是从IIIA阶段下降的候选人.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
手术病理学手术病理学

背景情况:

日本的IIIA期结肠直肠癌 (CRC) 的预后比II期CRC更好.
调查pT1CRC中淋巴结转移 (LNM) 的影响至关重要.
探索pT1N1CRC降级的可能性是合理的.

研究的目的:

确定pT1结直肠癌 (CRC) 患者淋巴结转移 (LNM) 的预后影响.
根据LNM状态来评估pT1N1 CRC下降阶段的可能性.

主要方法:

在日本对723名彻底切除的PT1CRC患者进行了回顾性队列研究.
根据淋巴结转移的存在 (LNM+) 或不存在 (LNM-) 进行分组的患者.
在倾向性得分匹配之前和之后的无复发存活率 (RFS) 和癌症特异性存活率 (CSS) 的比较.

主要成果:

在13.3%的患者中存在LNM,主要是N1.1.
在匹配之前,LNM+瘤更大,淋巴/血管入侵率更高,手术时间/住院时间更长.
在匹配后,在LNM+和LNM-组之间没有观察到RFS或CSS的显著差异;LNM+状态不是一个独立的风险因素.

结论:

淋巴结转移 (LNM) 不会影响pT1N1CRC患者的长期存活率.
具有低复发因子的pT1N1CRC可能适合从IIIA阶段降级.

关键词:

淋巴结转移 (LNM) 的发生.在pT1结直肠癌 (pT1 CRC) 中.倾向性得分匹配 (PSM) 是一种方法.

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