使用来自美国大陆以外的捐赠者进行肺移植的结果
Reed T Jenkins1, Emily L Larson1, Alice L Zhou1
1Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JHLT open
|July 21, 2025
概括
使用来自美国大陆以外的捐赠者的肺移植显示出与使用大陆捐赠者的肺移植相似的存活率. 这有助于扩大捐赠者库,考虑选择非大陆捐赠者进行肺移植.
科学领域:
- 器官移植研究器官移植研究
- 胸部手术的结果 胸部手术的结果
- 公共卫生和捐赠者管理
背景情况:
- 地理限制和捐赠者-接受者距离正在重新评估,以扩大肺移植捐赠者池.
- 这项研究专门研究了位于美国大陆以外的捐赠者器官的利用和结果.
研究的目的:
- 评估使用来自美国大陆以外捐赠者的肺部器官的安全性和有效性.
- 为了比较来自大陆和非大陆捐赠者的肺移植之间的移植后生存率.
主要方法:
- 来自美国器官共享网络数据库 (2005-2022) 的成年肺部移植的分析.
- 基于供体位置的移植的分类 (美国大陆与非大陆).
- 使用时间到事件方法和多变量考克斯回归的生存分析.
主要成果:
- 在35,638例肺移植中,有1.1%使用了非大陆捐赠者.
- 非大陆捐赠者和接受者通常具有较低风险的特征 (例如,年龄较小,BMI较低,吸烟史较少).
- 尽管距离更远,缺血时间更长,但使用非大陆供体的移植与大陆供体相比,移植后1年和5年生存率相似.
结论:
- 从选定的非大陆捐赠者的肺移植显示出与大陆捐赠者的肺移植结果相似的结果.
- 这些发现支持通过考虑从美国大陆以外的精心挑选的捐赠者来扩大肺捐赠者池.
- 这种方法可以帮助解决器官短缺问题,同时保持患者安全和移植存活率.
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