使用口服硫酸盐片肠道制剂增加侵蚀性胃炎的风险:一个回顾性单中心队列研究
Tara Alleyasin1, Jeffrey Nguyen1, Natalie A Savini1
1Department of Internal Medicine, Scripps Clinic/Green Hospital, San Diego, CA, USA.
Gastroenterology research
|July 21, 2025
概括
与聚乙烯糖醇 (PEG) 相比,用于结肠镜制备的口服硫酸盐片 (OST) 显示胃和侵蚀的风险更高. 需要进一步的研究来证实这些发现,并了解OST的风险.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服硫酸盐片 (OST) 是美国食品和药物管理局批准的结肠镜片制剂,其可口性和方便性高于聚乙烯糖醇 (PEG).
- 虽然对于炎症性肠病 (IBD) 患者存在警告,但使用OST的非IBD患者的胃侵蚀性疾病的记录较少.
- 零星的营销后报告表明,在使用OST时出现胃炎和胃.
研究的目的:
- 为了比较成年患者接受OST和PEG治疗的侵蚀性胃炎的发病率,在同一天食道胃管腺镜检查 (EGD) 和结肠镜检查之前.
- 评估与OST肠道准备相关的胃和侵蚀的发生情况.
主要方法:
- 一项单中心,盲目,回顾性研究将177名OST患者与219名PEG患者进行了匹配.
- 数据包括患者人口统计数据,手术细节和同一天的EGD和结肠镜病理报告.
- 分析重点是确定和比较两个制剂组之间的胃和侵蚀率.
主要成果:
- 与PEG组相比,OST组的胃 (13.6%与2.3%,P < 0.001) 和侵蚀 (16.9%与5.0%,P < 0.001) 发生率明显较高.
- 在OST和PEG组之间,在和侵蚀的位置上没有观察到显著的差异.
- 这些发现表明,OST与胃粘膜损伤增加之间存在统计学意义上的关联.
结论:
- 与PEG相比,在同一天接受EGD和结肠镜检查的患者中,OST肠道准备与侵蚀性胃炎的发病率更高.
- 需要进一步的前性随机研究来确认这些风险,并阐明OST诱导的粘膜损伤的机制.
- 这些发现表明需要仔细考虑OST的使用,特别是在接受联合手术的患者中.
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