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高风险的酒精消费与艾滋病毒感染者的线粒体损伤相关的分子模式有关

Shannon R Gilstrap¹, Micheal D Ho², Joanna M Hobson³

¹Department of Psychology, Samford University, Birmingham, AL, USA.

Drug and alcohol dependence reports

|July 21, 2025

概括

高风险的饮酒会显著增加艾滋病毒感染者 (PWH) 疼痛后的线粒体损伤. 艾滋病毒感染可能会使酒精恶化.

科学领域:

生物医学科学生物医学科学
免疫学免疫学免疫学
毒理学毒理学毒理学

背景情况:

酒精使用障碍在艾滋病毒感染者 (PWH) 中很普遍,导致不良健康结果.
酒精对PWH线粒体功能的影响尚不清楚.
线粒体损伤可能会在PWH中调解与酒精有关的健康问题.

研究的目的:

研究PWH和HIV阴性个体中高风险饮酒和线粒体损伤相关分子模式 (mDAMPs) 之间的关系.
检查艾滋病毒状况如何影响酒精消费对mDAMPs的影响.
评估mDAMPs对实验性疼痛压力的反应性,与酒精使用和艾滋病毒状况相关.

主要方法:

122名参与者的血清样本 (51名HIV+,71名HIV-) 用实时PCR分析了mDAMPs (ND1,ND6).
使用酒精使用障碍识别测试-C (AUDIT-C) 来测量高风险的酒精消费.
参与者进行了实验性疼痛测试,以评估mDAMPs的反应.

主要成果:

在疼痛测试 (p=0.045,p=0.047) 后,高风险饮酒的PWH显示mDAMPs (ND1和ND6) 显著升高 (p=0.045,p=0.047).
艾滋病病毒状况似乎影响了高风险饮酒和线粒体损伤之间的联系.
实验性疼痛加剧了PWH中酒精诱导的线粒体损伤标志物.

结论:

高风险的酒精消费对PWH的线粒体健康构成重大风险.
艾滋病毒感染可能会放大酒精诱导的线粒体功能障碍.
需要进一步的研究来了解和减轻PWH中的这些风险.

关键词:

使用酒精使用酒精艾滋病病毒艾滋病病毒艾滋病病毒线粒体中的线粒体.

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