相关实验视频

Updated: Sep 14, 2025

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

聚 (乙基甲酸) 唾液凝:一种基于聚合物的溶液,用于治疗口症

Suman Debnath¹, Cristina Paz², Dimitri Scofield^2,3

¹Charles D. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 USA.

ACS applied polymer materials

|July 21, 2025

概括

一种新的聚乙甲酸 (PHEMA) 唾液凝为口腔干燥 (xerostomia) 提供了一种非侵入性治疗方法. 这种可重复使用的凝有效地吸收和释放人造唾液,从口腔干燥中提供持续的缓解.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
口腔医学是指口腔医学.

背景情况:

口腔干燥 (xerostomia) 显著影响吞,言语和口腔卫生.
目前的异口症治疗只能提供暂时的缓解,或者是侵入性的.

研究的目的:

开发一种非侵入性,生物相容的唾液凝,使用聚乙甲酸 (PHEMA) 用于施瘤治疗.
模仿天然的唾液分泌特性,以保持口腔水分.
为了评估PHEMA基凝的胀,唾液保留和释放特征.

主要方法:

一种基于PHEMA的唾液凝的制造.
评估凝的膨胀能力和人工唾液的吸收.
在体温下测量人工唾液释放率.
在多个循环中评估凝的可重复使用性.

主要成果:

唾液凝在6小时内达到大约400%的胀.
它在体温下在4小时内表现出97%的高人工唾液释放效率.
凝在五个吸收释放周期中保持了一致的性能,表明可重复使用.

结论:

开发的PHEMA唾液凝显示出作为异口症的非侵入性治疗方法的巨大潜力.
它的特性与提供及时和持续缓解口腔干燥症状的目标保持一致.
该材料的生物相容性和可重复使用性支持其临床适用性.

关键词:

生物启发的唾液凝口腔护理材料的使用这是一种基于PHEMA的唾液凝.唾液释放的动态唾液释放的动态克塞罗斯托米亚 (Xerostomia) 是一种

更多相关视频

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

相关概念视频

Salivary Glands and Saliva

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...