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Updated: Sep 14, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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加速和区域选择性切换在1,3-双极循环添加反应中的加速和区域选择性切换,这些反应被限制在一个双体[4]pyrrole子中

Yifan Li1,2, Gemma Aragay1, Pablo Ballester1,3

  • 1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST) 43007 Tarragona Spain pballester@iciq.es.

Chemical science
|July 21, 2025
PubMed
概括

八胺1通过封闭加速1,3-双极循环加法反应高达2000倍. 这种超分子催化也切换了区域选择性,证明了对反应结果的精确控制.

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