在糖尿病患者的前列腺跨膜活检中,可能仍然需要抗生素预防:一项队列研究
1Department of Urological Surgery, Xiangshan County First People's Hospital Medical Health Group, Zhejiang, China.
Frontiers in medicine
|July 21, 2025
概括
抗生素预防可显著减少尿路感染和相关症状在糖尿病患者进行跨关节前列腺活检. 这种预防措施对于改善患者在手术后的结果至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 甲经前列腺活检 (TP-PB) 是诊断前列腺癌的标准程序.
- TP-PB携带尿路感染 (UTI) 的风险,报告的发病率高达3%.
- 糖尿病患者可能在侵袭性手术后患有感染的风险增加.
研究的目的:
- 在糖尿病患者中调查TP-PB相关感染的发生率.
- 为了比较接受抗生素预防 (AP) 和未接受抗生素预防的糖尿病患者之间的感染率.
主要方法:
- 一个单一的,比较的,观察性队列研究包括246名糖尿病男性接受TP-PB.
- 患者被分为两组:没有抗生素预防 (n=120) 和为期3天的口服抗生素预防 (n=126).
- 收集的数据包括症状,尿液培养,尿道感染发病率和活检后两周内与活检相关的后果.
主要成果:
- 与没有抗生素预防的组相比,接受抗生素预防的组显示无症状细菌性尿症 (0.8%与6.7%相比),尿路刺激症状 (4.0%与25.0%相比),发烧 (0.8%与7.5%相比) 和尿路感染 (0.8%与4.2%) 的比率明显较低.
- 在这两组中都没有报告任何败血症病例.
- 前列腺特异性抗原水平和前列腺癌检测率在两组之间相似.
结论:
- 抗生素预防有效地减少了糖尿病患者的跨关节前列腺活检相关感染的发生率.
- 这些发现支持使用AP来减轻与TP-PB相关的感染风险.
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