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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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设计一个基于细胞的直角性ubiquitin转移级联,以分析RBR E3帕金基的基底

Shuai Fang1,2, Li Zhou2, Geng Chen2

  • 1Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

iScience
|July 21, 2025
PubMed
概括

帕金是一种E3的ubiquitin结合酶,其基质使用一种新的直角性ubiquitin转移 (OUT) 级联来识别. 这种方法揭示了帕金在细胞循环和新陈代谢中的新角色,超出了线粒菌的范围.

关键词:
生物化学 生物化学生物分子工程是生物分子工程.生物科学中的方法论.蛋白质蛋白质是一种蛋白质.结构生物学是结构生物学.

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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