奎尔对剖腹产后术后疼痛管理的辅助作用:一项随机对照研究
Eman Mohamed Elmokadem1, Dina Khaled Abou El Fadl1, Ahmed M Bassiouny2,3
1Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt.
Drug design, development and therapy
|July 21, 2025
概括
手术前使用的奎尔素显著降低了剖腹产后的疼痛,延迟了对止痛药的需要,并使患者能够更早地动员. 这种天然的黄胺显示了作为一个安全的补充在剖腹产后疼痛管理策略的承诺.
科学领域:
- 产科和妇科 产科和妇科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 剖腹产后的疼痛是一个重要的临床挑战,影响着母亲的康复和幸福感.
- 奎尔塞丁是一种具有抗炎性质的黄类化合物,已显示出临床前止痛潜力,但缺乏针对急性疼痛的强有力的临床数据.
- 有效的疼痛管理策略对于改善剖腹产后的结果至关重要.
研究的目的:
- 评估手术前口服奎尔在治疗剖腹产后急性术后疼痛方面的疗效.
- 为了确定Quercetin的管理是否影响了救援止痛和患者动员的需要.
- 在这个患者群体中评估术前奎尔丁的安全性.
主要方法:
- 一项前性,双盲,随机对照试验,涉及80名接受选择性剖腹产的患者.
- 参与者在手术前一小时接受500毫克口服奎尔西或安慰剂.
- 疼痛强度 (VAS),第一次止痛要求的时间,以及其他恢复指标都在术后进行评估.
主要成果:
- 奎尔在所有测量时间点 (p<0.001) 上显著降低视觉模拟尺度 (VAS) 疼痛评分 (p<0.001).
- 奎尔塞丁组的患者经历了延迟的第一次止痛要求 (3.9对2.73小时,p<0.001) 和较早的体育活动启动 (15.2对19.03小时,p<0.001).
- 两组之间在吗啡消费,功能活动,恶心/吐或不良事件方面没有发现显著差异.
结论:
- 术前 奎尔素有效地缓解剖腹产后的急性术后疼痛.
- 奎尔赛丁可促进患者更早的动员,并减少对救援止痛药的需求,而不会影响安全.
- 奎尔是剖腹产时多式疼痛管理的有希望的补充剂.
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