精密瘤学和个性化疫苗开发中的纳米粒子技术:挑战和进步
Saber Imani1, Samaneh Moradi2, Tola Abdulsattar Faraj3
1Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
International journal of pharmaceutics: X
|July 21, 2025
概括
纳米粒子 (NP) 正在通过实现向药物递送系统 (DDS) 和增强免疫疗法来彻底改变癌症治疗. 本综述涵盖了各种NP平台及其对个性化,有效的抗癌疗法的潜力.
科学领域:
- 纳米医学是一种纳米医学.
- 在瘤学瘤学.
- 药物输送系统 药物输送系统
背景情况:
- 纳米粒子 (NP) 在推进精密瘤学方面起着至关重要的作用.
- 药物输送系统 (DDS) 利用NP提高精确医学,免疫干预和向治疗.
研究的目的:
- 审查临床相关的NP平台 (脂质,聚合物,金属基,陶,碳基,aptamer-conjugated,量子点) 用于瘤学的治疗和诊断应用.
- 探索下一代系统,如混合NP,刺激响应NP和人工智能导向NP用于癌症疫苗和免疫治疗.
- 讨论NP功能作为DDS,包括抗原释放,抗原呈现细胞输送和基于新抗原的免疫疗法.
主要方法:
- 在瘤学中纳米粒子平台的文献综述.
- 分析NP在药物输送,免疫疗法和基于细胞的疗法中的作用.
- 探索癌症治疗纳米医学的挑战和未来方向.
主要成果:
- 各种NP平台在向癌症治疗和诊断方面显示出显著的潜力.
- 下一代NP为先进的癌症治疗提供可编程和适应能力.
- 抗原蛋白促进控制的抗原递送,增强免疫疗法的疗效,并有助于克服多种药物耐药性.
结论:
- 纳米颗粒在个性化瘤学中是一个有希望的前沿,提供了改进的治疗和诊断策略.
- 尽管存在发展障碍,但纳米医学的进步正在为具有临床益处的有效,个性化的抗癌疗法铺平道路.
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