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Updated: Sep 14, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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VX-445 (elexacaftor) 通过直接阻断KCa3.1通道,通过人类支气管上皮细胞抑制化物分泌

Aaron Kolski-Andreaco1, Corina M Balut2, Matthew D Green2

  • 1Department of Cell Biology, University of Pittsburgh, 3500 Terrace St., Pittsburgh, PA 15261, USA.

PNAS nexus
|July 21, 2025
PubMed
概括

囊性纤维化 (CF) 药物VX-445通过阻断关键通道 (KCa3.1) 来意外抑制肺细胞中的化物分泌. 这一发现表明CFTR校正疗法的潜在局限性.

关键词:
主要分类:生物科学 生物科学较小的分类:药理学药理学不良事件不良事件不良事件囊性纤维化症是什么离子通道 离子通道

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