陈诺二氧化醇酸激活TGR5/TRPA1-5-HT通路,以调节母乳养婴儿和小鼠模型的肠道运动
Zihong Shan1,2, Chenghui He1,2, Qingyao Yang1,2
1Department of Pediatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Translational pediatrics
|July 21, 2025
概括
陈氧胆酸 (CDCA) 影响婴儿的肠道排便. 这项研究发现CDCA通过TGR5/TRPA1-5-HT信号通路影响母乳养婴儿的排便频率,促进肠道运动.
科学领域:
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
- 代谢学 代谢学 代谢学
背景情况:
- 众所周知,陈氧胆酸 (CDCA) 影响肠道运动和胃肠道 (GI) 疾病.
- 在母乳养婴儿的排便模式中,CDCA的具体作用尚不清楚.
- 这项研究调查了CDCA和肠道排便频率之间的联系.
研究的目的:
- 探索CDCA水平和母乳养婴儿排便频率之间的关系.
- 阐明CDCA影响肠道运动的生理机制.
- 为了确定潜在的信号通路,涉及到CDCA介导对肠道排便的影响.
主要方法:
- 婴儿便样本中CDCA水平的代谢分析与排便频率相关.
- 鼠类模型评估CDCA对结肠过境和便水含量的影响.
- 在实验室细胞研究中,使用大鼠胰岛素瘤衍生细胞来研究5-基三胺 (5-HT) 分泌.
主要成果:
- 在小鼠中,CDCA的使用增加了胃肠道过渡,便中的水含量,并减少了过渡时间,没有结肠损伤.
- 在小鼠模型中,CDCA刺激了5-HT分泌,并上调了Tph1,TGR5和TRPA1信号分子.
- 这些途径的抑制使肠道运动和5-HT分泌正常化,证实了它们的机械作用. 此外,CDCA还增加了老鼠细胞中的5-HT分泌.
结论:
- 在母乳养的婴儿中,CDCA水平与排便频率有显著的相关性.
- CDCA可能通过TGR5/TRPA1-5-HT信号轴调节肠道运动.
- 这种途径为CDCA对婴儿肠道运动的影响提供了机制性的解释.
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