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相关概念视频

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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相关实验视频

Updated: Sep 14, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

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针对 Trop2 的免疫oPET 配体.

Steven H Liang1

  • 1Department of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, United States.

American journal of nuclear medicine and molecular imaging
|July 21, 2025
PubMed
概括

瘤生物标志物Trop2是免疫oPET成像剂的目标. 这些由抗体和纳米体衍生出来的药物揭示了Trop2的存在.

科学领域:

  • 在瘤学瘤学.
  • 生物标志物 生物标志物
  • 分子成像学分子成像学

背景情况:

  • 在各种瘤类型中,Trop2经常过度表达.
  • 在癌症研究和临床实践中,Trop2是重要的生物标志物.

研究的目的:

  • 探索针对性免疫oPET连接体对可视化Trop2表达的有用性.
  • 评估immunoPET在改善癌症诊断,分期和治疗策略方面的潜力.

主要方法:

  • 基于Trop2单克隆抗体和纳米体的向免疫oPET配体的开发.
  • 利用这些连接体来绘制瘤中Trop2的异质表达模式.

主要成果:

  • 免疫PET配体有效地可视化了瘤中Trop2表达的景观.
  • 在不同瘤部位的Trop2表达中显示异质性.

结论:

  • 针对Trop2的向性免疫oPET成像为癌症可视化提供了一个有前途的方法.
  • 这项技术具有显著的潜力,可以提高癌症诊断,分期和治疗选择的准确性.
关键词:
热囊细胞细胞表面抗原2 (Trop2)免疫PET连接体的免疫PET连接体在活体中成像成像纳米体是一个纳米体.瘤是一个瘤.

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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

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