在COVID-19康复个体内内分泌功能测试的异常
Phibakordor L Nonglait1, Srivenkata Madhu1, Nishant Raizada1
1Department of Endocrinology, Centre for Diabetes Endocrinology and Metabolism, Delhi, India.
Indian journal of endocrinology and metabolism
|July 21, 2025
概括
COVID-19可能会导致持久的内分泌系统问题,影响垂体,甲状腺和淋巴腺轴. 这些异常在康复后持续数月,影响长期健康.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19对内分泌系统的影响与广泛的血管素转化酶-2 (ACE2) 受体分布有关.
- 以前的研究主要集中在急性COVID-19期间的内分泌变化.
- 康复个体的长期内分泌后果需要全面评估.
研究的目的:
- 在从COVID-19中恢复过来的个人中调查内分泌异常.
- 为了评估内分泌功能障碍的流行和类型,COVID-19后恢复.
- 了解对长期内分泌和代谢健康的影响.
主要方法:
- 招募了83名COVID-19康复个体 康复后8-20周.
- 根据COVID-19疾病严重程度 (轻度与中度至重度) 进行分层的患者.
- 评估炎症标志物和下丘脑-垂体轴 (甲状腺,上腺,淋巴腺,乳腺蛋白).
主要成果:
- 53%的参与者在COVID-19后表现出内分泌功能障碍.
- 中枢垂体轴功能障碍发生在33.7%的人群中,其中最常见的是益生素变化 (20.4%).
- 甲状腺功能异常在30.1%的男性中被发现,性腺功能障碍在14%的男性和6%的女性中被发现.
结论:
- 显著的内分泌功能测试异常在COVID-19复苏后的3个月内持续存在.
- 这些发现强调了需要仔细解释康复患者内分泌测试的必要性.
- 这些异常对COVID-19幸存者的长期内分泌和代谢健康有影响.
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