马类传染性贫血的全球流行率和危险因素:系统性审查和元分析
Lintang Winantya Firdausy1,2, Faisal Fikri1,2, Arya Pradana Wicaksono3
1Division of Veterinary Medicine, Department of Health and Life Sciences, Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Banyuwangi, East Java, 68425, Indonesia.
马类传染性贫血 (EIA) 影响全球的马类动物,总体患病率为20.97%. 加强监测和标准化诊断对于控制这种隐形病毒性疾病至关重要.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 动物健康 动物健康
背景情况:
- 马传染性贫血 (EIA) 是一种影响马类的全球性隐形病毒性疾病,具有重大生物安全风险.
- 关于EIA流行和风险因素的现有数据是分散的,需要进行全面的综合分析.
研究的目的:
- 系统地审查和对全球EIA患病率进行元分析.
- 识别诊断趋势并评估有助于研究异质性的因素.
主要方法:
- 在六个主要数据库中系统地搜索1975-2024年的研究.
- 使用随机效应模型对29项符合条件的研究进行元分析.
- 亚组分析和元回归来探索异质性.
主要成果:
- 全球聚合EIA患病率估计为20.97%,具有显著的异质性 (I2 = 99.3%).
- 南美洲 (27.21%) 和马 (25.40%) 患病率和易感性最高.
- 从2015年至2022年期间观察到患病率下降的趋势 (2.19%-28.70%);气候和研究期间影响了异质性.
结论:
- 严重的全球负担和EIA的诊断变异性需要改进监测和标准化的协议.
- 加强隔离实践和扩大血清学监测至关重要.
- 整合气候和生态数据可以帮助缓解EIA传播.
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