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胆膜炎对早产婴儿死性肠球炎的影响:一个多中心队列研究

Xin Guo¹, Jiaming Xian¹, Xianhong Chen^2,3

¹Department of Neonatology, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, Guangdong, China.

Frontiers in pediatrics

|July 21, 2025

概括

孕产妇膜炎 (CAM) 暴露与死性肠球炎 (NEC) 的增加或非常早产婴儿的死亡有关. 已确认的CAM和早产膜破裂显著增加了这种风险.

科学领域:

新生儿科学新生儿科学
产科产科产科产科产科
儿科手术儿科手术

背景情况:

胆 ?? 膜炎 (CAM) 是一种胎盘炎症,具有潜在的新生儿不良后果.
死性肠球炎 (NEC) 是一种严重的胃肠道疾病,影响脆弱的早产婴儿.
了解CAM-NEC关联对于改善新生儿存活率至关重要.

研究的目的:

调查在非常早产婴儿 (VPI) 或出生时体重非常低的婴儿 (VLBWI) 中,母体胆炎 (CAM) 和死性肠球炎 (NEC) 之间的关联.
检查CAM不同阶段对NEC发育和住院死亡率的影响.
评估膜过早破裂对CAM-NEC关系的改变作用.

主要方法:

一项在深在2022-2023年间进行的多中心队列研究.
包括非常早产婴儿或出生时体重非常低的婴儿暴露于母亲的CAM.
对混因素进行了调整后勤回归分析,对膜过早破裂进行了分层.

主要成果:

CAM的患病率为44.31%,NEC为5.38%,NEC或死亡率为7.69%.
接触CAM与增加NEC或死亡风险相关 (aOR=1.90).
经确认的CAM (aOR=7.14) 和早产膜破裂的CAM (aOR=2.18) 与不良结果的关联性更强.

结论:

母亲CAM显著增加了非常早产婴儿和VLBWI的NEC或死亡的风险.
这种联系在已确认的CAM病例中尤为强烈.
在膜过早破裂后出生的早产婴儿在CAM暴露和不良结果之间表现出更显著的联系.

关键词:

胆 ?? 阴性炎是一种胆 ?? 阴性炎.死亡死亡死亡死亡死亡死亡死性肠球炎 (necrotizing enterocolitis) 是一种致死性肠球炎.非常低的出生体重婴儿婴儿非常早产的婴儿非常早产的婴儿

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