类风湿性关节炎和心房动:一个复杂的心血管交叉点 - - 从回顾性队列研究的见解
Qusai Alqudah1,2, Ahmad Alomari1,2, Moh'd Daise1,2
1University of Central Florida College of Medicine, Graduate Medical Education, Orlando, USA.
Medical archives (Sarajevo, Bosnia and Herzegovina)
|July 21, 2025
概括
患有类风湿性关节炎 (RA) 和心房动 (AF) 的患者面临更高的死亡率和中风风险. 抗凝药的使用在RA-AF患者中较低,尽管心血管事件风险增加.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 与心血管疾病 (CVD) 和心房动 (AF) 风险增加有关.
- 关于RA患者的AF临床结果和管理的数据有限.
研究的目的:
- 评估RA对AF相关结果的影响.
- 评估RA患者的AF治疗策略.
主要方法:
- 使用 TriNetX 美国协作网络数据库 (2015-2025) 的回顾性队列研究.
- 被诊断为AF的成年患者被分为RA和非RA队列.
- 倾向性得分匹配用于平衡基线特征.
主要成果:
- 分析了33922名RA-AF患者和33922名非RA AF患者.
- 在RA-AF患者中,全因死亡率 (24.5%对21.0%),住院率 (72.2%对69.2%),缺血性中风/TIA (13.2%对11.4%) 和出血事件 (14.4%对10.6%) 较高.
- 快速腹腔反应的AF在RA-AF患者中更常见 (36.1%与33.5%相比),使用抗凝剂较少 (46.9%与49.4%相比),并且更喜欢控制速率.
结论:
- 与非RAAF患者相比,RA-AF患者面临的死亡率,中风,出血事件风险和住院率显著增加.
- 抗凝固药物使用不足是RA-AF患者的一个重大问题,尽管风险较高.
- 在RA-AF患者的治疗策略倾向于节律控制而不是节律控制.
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