一个关于草药治疗认知障碍的机制的观点
Si-Yuan Zheng1,2, Xiao-Qing Zhou3
1Department of Encephalopathy, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in neurology
|July 21, 2025
概括
草药提供了一种多目标方法,通过调节关键分子通路来对抗认知障碍 (CI). 这种系统层面的策略显示了比传统的单分子疗法更有效的CI治疗的希望.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 认知障碍 (CI) 是一个日益严重的公共卫生问题,治疗选择有限.
- 针对单个分子的传统疗法通常不足以治疗复杂的CI病理.
- 草药通过调节多个途径提供了系统级的方法.
研究的目的:
- 审查草药疗法的药理机制,以减轻认知障碍.
- 突出了参与CI的关键分子通路的调节.
- 评估草药作为CI的替代或补充治疗的潜力.
主要方法:
- 对临床前和临床研究的专注文献综述.
- 确定检查PI3K/Akt,Nrf2/HO-1,NF-κB和BDNF/TrkB通路的草药调节的研究.
- 对代表性草药化合物和提取物的分析.
主要成果:
- 草药疗法调节关键通路 (PI3K/Akt,Nrf2/HO-1,NF-κB,BDNF/TrkB) 以减少氧化应激和炎症.
- 诸如金氏,卡塔尔波尔和金氏和Huperzia serrata的提取物等化合物显示出有前途的结果.
- 草药提供了更广泛的药学动力学谱,潜在的副作用比单一疗法更少.
结论:
- 草药提出了一个可行的系统级策略来管理认知障碍.
- 将草药疗法纳入IC治疗计划得到了当前证据的支持.
- 需要进一步进行高质量的临床试验和机制研究,以优化CI的草药应用.
更多相关视频
10:33Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
Published on: November 18, 2022
1.4K
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
209
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
209
01:22Alzheimer's Disease: Treatment
262
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
262
01:30Cognitive Development During Adulthood
288
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
288
01:23Role of Neurotransmitters in Memory
996
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
996
01:26Alzheimer's Disease: Overview
669
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
669
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
334
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
334