低密度粒细胞在急性胰腺炎中的临床意义
Jiren Wang1, Xinwen Chen1, Youli Ke1
1Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.
Mediators of inflammation
|July 21, 2025
概括
增加的低密度粒细胞 (LDGs) 表明急性胰腺炎 (AP) 的严重程度增加. 较高的LDG水平与较差的临床标志物相关,并预测中度至重度的AP,表明它们在疾病活动中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 临界护理医学 临界护理医学
背景情况:
- 低密度颗粒细胞 (LDG) 是一个独特的中性粒细胞子集,在免疫-炎症条件中具有已知的作用.
- LDG在急性胰腺炎 (AP) 病理生理学和临床进展中的具体参与尚未得到充分定义.
研究的目的:
- 确定周围血液LDG水平与急性胰腺炎的临床严重程度之间的关联.
- 评估LDGs作为预测AP严重程度和复发的潜在生物标志物.
主要方法:
- 一项涉及41名轻度AP (MAP),40名中度至重度AP (SAP) 患者和41名健康对照组 (HC) 的横截面研究.
- 周围的LDG在入院后24小时内得到量化.
- 使用统计分析,包括克鲁斯卡尔-瓦利斯测试,物流回归和ROC分析,以评估相关性和预测价值.
主要成果:
- 与MAP和HC相比,SAP患者的LDG水平显著升高 (p < 0.001).
- 较高的LDG与白细胞计数,葡萄糖,中性粒细胞与淋巴细胞的比率,APACHE II和BISAP得分 (p <0.05) 有积极的相关性.
- LDG独立预测了中度至重度的AP (AUC = 0.967,95.0%灵敏度,90.2%的特异性在2.96%的截止值) 并与更高的复发风险有关.
结论:
- 周围LDG水平升高与急性胰腺炎的疾病活性和严重程度增加有显著的关联.
- LDGs显示出作为早期风险分层和预测AP患者结果的有价值生物标志物的潜力.
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