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Updated: Sep 14, 2025

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在性结肠炎中,HMGB1通过TLR4/NF-κB/GPX4通路诱导铁死,加剧肠壁损伤

Nannan Zhu1, Xiaoyuan Ge1, Lixue Zhang1

  • 1Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.

Mediators of inflammation
|July 21, 2025
PubMed
概括

高流动性组盒-1蛋白 (HMGB1) 通过驱动铁亡并破坏肠道屏障,加剧性结肠炎 (UC). 准HMGB1-TLR4/NF-κB/GPX4通路为UC提供了一个潜在的治疗策略.

关键词:
这就是HMGB1的特点.通过TLR4/NF-κB/GPX4路径.铁性化 (ferroptosis) 是一种肠道屏障 肠道屏障 肠道屏障性结肠炎是一种

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