局部管理纳米颗粒的增强表面透性和保留效应
Yiyang Chen1, Zhenghong Liu2, Bin Zheng2
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Journal of drug targeting
|July 21, 2025
概括
纳米颗粒的局部管理提供了一个直接的,更安全的途径到瘤,绕过系统循环. 这种方法利用增强的表面透性和保留 (ESPR) 效应用于局部瘤治疗,而无需接体受体向.
科学领域:
- 纳米医学是一种纳米医学.
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
背景情况:
- 静脉纳米粒子输送在实现局部瘤效应方面面临挑战,并可能导致全身毒性.
- 局部施用提供了直接通往瘤表面的途径,可能提高治疗疗效和生物安全性.
- 增强的表面透性和保留 (ESPR) 效应描述了利用瘤表面特征的纳米粒子行为.
研究的目的:
- 审查当前局部施用基于纳米粒子治疗的临床状况.
- 阐明ESPR效应对内腔纳米粒子的机制.
- 总结ESPR效应在局部纳米粒子传递中的调节策略.
主要方法:
- 当前临床应用局部纳米粒子管理的文献综述.
- 分析ESPR效应背后的生物物理原理.
- 综合影响ESPR因素和潜在调制技术的数据.
主要成果:
- 局部施用可使局部纳米粒子传递到瘤表面,与静脉注射途径相比,改善治疗结果和生物安全性.
- 该ESPR效应促进纳米颗粒扩散和向运输到瘤组织,独立于特定的连接体-受体相互作用.
- 了解和调节ESPR是优化局部基于纳米粒子的癌症治疗的关键.
结论:
- 局部纳米颗粒的管理代表了局部癌症治疗的有希望的策略,具有增强的安全性.
- ESPR效应是一个关键的机制,可以通过局部递送在瘤中准纳米粒子积累.
- 对ESPR调节的进一步研究可以优化局部纳米粒子疗法,以提高临床疗效.
相关概念视频
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
268
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
268
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.0K
Non-Oral Extravascular Drug Absorption Routes
298
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
298
Factors Affecting Drug Distribution: Tissue Permeability
298
The drug distribution process within the human body is a complex interplay of various physicochemical properties inherent to the drugs. These properties, including molecular size, ionization degree, partition coefficient, and stereochemical nature, significantly impact how drugs permeate biological membranes to reach their target tissues.
Small molecules with a molecular weight below 500 to 600 Daltons can easily pass through the capillary membrane, gaining access to different tissues. Larger...
Small molecules with a molecular weight below 500 to 600 Daltons can easily pass through the capillary membrane, gaining access to different tissues. Larger...
298
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
2.0K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
2.0K
Factors Influencing Drug Absorption: Physicochemical Parameters
441
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
441


