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Updated: Sep 14, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

巴西A-29战斗机飞行员的急性代谢效应通过基于NMR的代谢学

Roberta Verissimo França de Oliveira¹, Grace Barros de Sá², Alanny Cristine Dos Santos Pinheiro¹

¹Laboratory of Metabolomics (LabMet), IBRAG/Department of Genetics, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Rio de Janeiro 20950-003, Brazil.

Journal of proteome research

|July 21, 2025

概括

战斗机飞行员的飞行任务会导致急性代谢变化,经验丰富的教练比学员更适应. 基于核磁共振 (NMR) 的代谢学有效监测这些生理变化.

科学领域:

航空航天医学航空航天医学
人体生理学人体生理学
代谢学代谢学代谢学

背景情况:

军用航空飞行员因飞行操作而面临严重的身体和精神压力.
诸如昼夜干扰,不规则的时间表和G力暴露等因素会影响飞行员生理.

研究的目的:

调查飞行操作对A-29战斗机飞行员的急性代谢影响.
为了比较飞行员学员和经验丰富的教练之间的代谢反应.

主要方法:

从32名巴西空军飞行员 (学员和教练) 收集了飞行前和后的血液,尿液和唾液样本.
进行人体测量测量,全血细胞计,循环内皮细胞,凝血图,脂质图,尿液分析和基于NMR的代谢学.

主要成果:

实习生显示了细分性中性粒细胞的增加 (+12%),而教练则增加了淋巴细胞数量 (+15%).
这两组都经历了血清乳酸水平的降低. 训练员的唾液葡萄糖增加了 (+49%),而教练则显示胆 (-23%) 和乳酸 (-15%) 的降低.
训练员表现出尿液中的三角蛋白显著增加 (+53%),表明更大的代谢适应.

结论:

急性飞行暴露会引起战斗机飞行员明显的代谢变化.
代谢反应在学员中显得更加明显,教练们表现出适应性变化.
基于NMR的代谢学是评估飞行员急性代谢变化的强大工具.

关键词:

这是一架A-29喷气式飞机.这就是G力.这就是NMR的NMR.急性新陈代谢急性新陈代谢血液血液血液血液血液战斗机飞行员飞行员的飞行员.代谢生物组的代谢生物组军事航空军事航空这是唾液,唾液.尿液尿液尿液

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