睡眠时间的不规则性和发生心血管疾病的风险在英国生物银行
Tianyi Huang1, Sina Kianersi2, Heming Wang2,3
1Laboratory of Epidemiology and Population Sciences, Intramural Research Program National Institute on Aging Baltimore MD USA.
Journal of the American Heart Association
|July 21, 2025
概括
睡眠时间的变化增加了心血管疾病的风险,尤其是长时间睡觉的人. 这种关联无论遗传倾向如何,都保持不变,强调睡眠的规律性是关键的健康因素.
科学领域:
- 心脏病学 心脏病学
- 睡眠科学 睡眠科学
- 公共卫生 公共卫生
背景情况:
- 循环节律的扰乱,以不一致的睡眠时间表明,与心血管疾病 (CVD) 风险的增加有关.
- 心血管疾病类型,平均睡眠时间和遗传倾向对这种关联的影响需要进一步调查.
研究的目的:
- 检查睡眠时间变化与重大心血管事件风险之间的关联.
- 确定这种关联是否在心血管疾病类型 (心肌梗塞,中风) 中存在差异,还是受到平均睡眠时间和遗传风险的改变.
主要方法:
- 使用7天加速计数据对86,219名英国生物库参与者的前性分析.
- 睡眠不规则,用睡眠时间的标准偏差 (SD) 来量化.
- 通过医院记录追踪的重大心血管疾病事件 (心肌梗塞,中风);用于分析的Cox比例危险模型.
主要成果:
- 睡眠时间增加1小时SD与心血管疾病风险增加19% (HR 1.19),心肌梗塞风险增加23% (HR 1.23) 和中风风险增加17% (HR 1.17) 相联系.
- 在调整了各种混因素后,这些关联仍然很重要.
- 睡眠不规则导致心血管疾病风险升高,不论遗传风险如何,但在睡眠时间超过8小时的人群中更为明显.
结论:
- 睡眠时间的夜间变化更大,始终与增加主要心血管疾病事件风险有关.
- 对心血管疾病的遗传风险没有改变这种关联.
- 与睡眠不规则相关的风险增加在长时间睡眠者 (平均睡眠时间>8小时) 中更为明显.
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