辅助增量普雷加巴林治疗导致慢性胰腺炎患者更好地缓解疼痛:双盲随机对照试验
Randeep Rana1, Samagra Agarwal1, Sumaira Qamar1
1Department of Gastroenterology and Human Nutrition Unit.
Journal of clinical gastroenterology
|July 21, 2025
概括
在患有慢性胰腺炎 (CP) 的患者中,Pregabalin在12周内有效减轻疼痛. 这项研究发现,pregabalin改善了CP患者的生活质量和疼痛干扰.
科学领域:
- 胃肠病学 胃肠病学
- 疼痛医学 医学 疼痛医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性胰腺炎 (CP) 疼痛管理仍然具有挑战性.
- 像普雷加巴林一样的加巴类药物已经显示出潜力,但需要在CP进行进一步的长期评估.
- 关于普雷加巴林治疗疼痛性脑脊髓炎的疗效和安全性的数据有限.
研究的目的:
- 评估pregabalin作为辅助治疗治疗疼痛缓解的有效性,在患有慢性胰腺炎疼痛的患者超过12周.
- 评估前加巴林对生活质量和日常活动干扰的影响.
- 为了确定该患者群体中普雷加巴林的安全性和耐受性.
主要方法:
- 一个为期12周的,双盲,随机的安慰剂受控试验.
- 患有疼痛性CP的患者 (没有活性炎症或阻塞) 接受了普雷加巴林或安慰剂.
- 主要结局:伊兹比基疼痛评分的变化. 二级结局:生活质量 (SF-36),疼痛干扰 (mBPI-SF) 和患者总体印象 (PGIC).
主要成果:
- 与安慰剂相比,普雷加巴林显著改善了伊兹比基疼痛评分 (P=0.005).
- 在整体生活质量和患者对变化的总体印象方面也观察到改善.
- 在普雷加巴林组 (P=0.008) 中,疼痛干扰日常活动显著减少 (P=0.008).
- 常见的副作用包括嗜睡和头,停药率低 (10.4%).
结论:
- 普雷加巴林作为一种有益的辅助疗法,用于治疗慢性胰腺炎患者的疼痛.
- 这项研究支持使用普加巴林来改善CP患者的疼痛评分,生活质量和日常功能.
- 普雷加巴林在疼痛性脑脊髓炎的长期使用中显示出有利的安全性.
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