非对称的听觉功能障碍作为帕金森病潜在的非运动横向标志:一项病例对照研究
Reham Mamdouh Lasheen1, Mohamed Nasser Elsheikh2, Mohamed Osama Tomoum3
1Assistant Professor of Audiovestibular Medicine, Faculty of Medicine, Tanta University, Egypt.
概括
听觉功能障碍在帕金森病 (PD) 中很常见,经常显示不对称. 这种侧面化的听力障碍可能成为诊断PD和了解其对感官系统的影响的宝贵生物标志物.
科学领域:
- 神经学 神经学
- 听力学 听力学是指听力学.
- 神经科学是一个神经科学.
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,其特点是运动症状,但听力功能障碍等非运动症状显著影响生活质量.
- 听力功能障碍越来越多地被认为是PD的特征,影响患者的福祉.
研究的目的:
- 为了评估PD患者的听力障碍.
- 评估听力功能障碍的不对称性作为区分PD与其他神经退行性疾病的潜在生物标志物.
主要方法:
- 包括60名帕金森症患者和40名健康对照.
- 在听力测试中使用纯音调听力测量 (PTA),听觉脑干响应 (ABR) 和耳声发射 (OAE).
主要成果:
- 患有PD的患者表现出明显更高的PTA值,特别是在受影响的侧面.
- 在PD患者中,ABR延迟时间延迟,在受影响的侧面更明显.
- 扭曲产品OAE幅度在PD患者中显著降低,特别是在受影响的一侧,并且低于对照组.
结论:
- 听力学反应在PD患者中的不对称性是一个重要的发现.
- 这种侧面化的听觉功能障碍可能是PD的有价值的非运动标志物.
- 它有助于理解PD对感官系统的影响,并可能改善诊断和监测.
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