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在破裂的宽动脉瘤中进行普拉苏格勒单疗时,使用hpc涂层设备进行支架辅助卷轴和流量转移:一个多中心病例系列

Abdallah Aburub¹, Stephan Felber², Hans Henkes³

¹Department of Diagnostic and Interventional Neuroradiology, Philipps University of Marburg, Marburg, Germany. abdullahaburub8@gmail.com.

|July 21, 2025

概括

在单一抗血小板疗法 (SAPT) 下使用性聚合物涂层装置的支架辅助卷轴 (SAC) 和流量转移 (FD) 对破裂的宽动脉瘤是安全有效的. 长期结果相似,支持SAPT在高风险患者中的可行性.

科学领域:

神经内血管治疗神经内血管治疗
脑血管外科手术脑血管手术
干预性神经放射学干预性神经放射学

背景情况:

宽子内动脉瘤带来了重大的治疗挑战.
水友性聚合物涂层 (HPC) 设备越来越多地用于内血管程序.
单一抗血小板治疗 (SAPT) 是可取的,以尽量减少出血风险.

研究的目的:

评估使用HPC设备的支架辅助卷轴 (SAC) 和流量转移 (FD) 的安全性和有效性.
评估Prasugrel SAPT下SAC和FD的临床结果,用于破裂的宽内动脉瘤.
为了比较SAC和FD之间的即时和长期封闭率和功能结果.

主要方法:

46名患有破裂宽内动脉瘤的患者的多中心回顾病例系列.
治疗方式包括在普拉苏格勒SAPT下使用HPC涂层设备的SAC和FD.
评估结果:技术上的成功,并发症,12个月后的闭塞率 (FU) 和修改的兰金度量表 (mRS).

主要成果:

100%的技术成功,周围手术并发症很少 (4.3%).
SAC显示出更高的立即封闭 (95.7%) 与FD (21.7%),但12个月封闭率是可比的 (100%与95%).
84%的患者获得了良好的功能结果 (mRS ≤2),两组之间没有显著差异.

结论:

在普拉苏格勒SAPT下使用HPC设备的SAC和FD对于破裂的宽动脉瘤是安全有效的.
虽然SAC提供了更好的立即阻塞,但SAC和FD的长期结果相似.
在这种高风险人群中,SAPT是可行的,因此需要进一步的前性研究.

关键词:

流量转移的转移流量转移的转移水友性聚合物涂层是一种水友性聚合物涂层.内动脉瘤是一个内动脉瘤.普拉苏格雷尔 (Prasugrel) 是一种药物.破裂的动脉瘤发生了破裂.单一抗血小板治疗是一种单一的抗血小板疗法.用支架辅助的卷轴,可以使用支架.

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