维生素D缺乏是50岁或以上人群认知能力下降的危险因素
Natália Cochar-Soares1, Thaís Barros Pereira da Silva1, Mariane Marques Luiz2
1Postgraduate Program in Gerontology, Federal University of Sao Carlos, Sao Carlos, Brazil.
GeroScience
|July 21, 2025
概括
维生素D缺乏与老年人更快的认知衰退有关,特别是在全球认知和执行功能方面. 维持足够的维生素D水平可能是保持老龄人口大脑健康的关键.
科学领域:
- 老年学是一门学科.
- 营养神经科学 营养神经科学
- 认知老龄化 认知老龄化
背景情况:
- 关于维生素D在老年人认知能力下降中的作用,存在相互矛盾的证据.
- 了解维生素D缺乏对认知轨迹的影响对于公共卫生至关重要.
研究的目的:
- 研究维生素D缺乏作为50岁及以上个体认知能力下降的危险因素.
- 分析维生素D状态与全球认知和特定认知领域的纵向变化之间的关联.
主要方法:
- 一项队列研究使用来自英国长度老龄化研究的2625名参与者 (年龄≥50岁) 的数据.
- 维生素D水平 (25-氧维生素D) 分类为足够,不足或缺乏.
- 认知表现通过口头流利性,词汇列表,时间导向和六年来全球认知测试来评估.
- 根据共变量调整的通用线性混合模型,以估计基于维生素D状态的认知衰退率.
主要成果:
- 与缺乏维生素D的参与者相比,具有足够水平的参与者在全球认知 (0.037 SD/年) 和执行功能 (0.038 SD/年) 中出现了显著较大的下降.
- 没有发现有关维生素D状态的记忆或时间导向轨迹的显著差异.
- 维生素D缺乏被确定为加速关键领域认知衰退的危险因素.
结论:
- 维生素D缺乏是导致老年人全球认知和执行功能下降的重要危险因素.
- 对维生素D水平的评估和管理对于促进认知健康和减轻与年龄相关的认知衰退至关重要.
- 进一步的研究可以探索有针对性的干预措施,以解决维生素D缺乏症的认知维护.
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