在没有病原体的情况下,维护和失去微生物介导的保护
Melinda Kemlein1, Lena Peters1, Hinrich Schulenburg1,2
1Department of Evolutionary Ecology and Genetics, University of Kiel; 24118 Kiel, Germany.
Journal of evolutionary biology
|July 21, 2025
概括
保护性微生物维持宿主防御,即使没有病原体. 有益细菌的高殖民性确保了对有害入侵者的持续保护,证明了共生稳定性.
科学领域:
- 微生物学 微生物学
- 生态生态学 生态生态学
- 进化生物学 进化生物学
背景情况:
- 保护性微生物通过抑制病原体,为宿主提供生存益处.
- 在没有病原体压力的情况下维持微生物介导的保护并未得到充分理解.
- 对宿主的共生体适应可能会影响保护能力.
研究的目的:
- 为了研究 Pseudomonas lurida MYb11.11 中微生物介导保护的稳定性.
- 评估细菌适应健康宿主如何影响保护性共生.
- 了解在没有病原体选择的情况下维持保护的机制.
主要方法:
- 进化的Pseudomonas lurida MYb11通过Caenorhabditis elegans的连续传递来分离.
- 评估进化分离物对Bacillus thuringiensis Bt247.7.的体外病原体抑制.
- 评估C. elegans.进化的分离物所赋予的宿主保护.
- 在受保护和不受保护的宿主中分析共生体殖民和病原体负载.
主要成果:
- 所有进化的MYb11分离物在体外抑制了Bt247.
- 大多数,但并非所有,进化的分离物保持宿主保护.
- 完整的保护与高的共生体殖民和较低的病原体水平相关.
- 孤立的MT5 (受保护) 和MT11 (不受保护) 突出了殖民的作用.
结论:
- 即使微生物适应宿主而没有病原体压力,保护性共生也可以保持稳定.
- 高的共生体殖民能力对于维持微生物介导的保护至关重要.
- 细菌适应宿主协会可以导致一些共生体的保护功能丧失.
关键词:
细菌 thuringiensis 这种疾病.凯诺哈比迪斯 (Caenorhabditis elegans) 是一个可爱的植物.伪虫 (Pseudomonas lurida) 是一种可怕的病毒.主体-微生物群相互作用.一个超生物体 (metaorganism) 是什么?通过微生物介导的保护.更多相关视频
07:44Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes
Published on: February 14, 2025
1.0K
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016
9.0K
相关概念视频
01:31Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
01:26Defense Mechanism Against Infection
7.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
7.2K
01:20Infection
8.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.7K
01:26Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
01:40Cell-mediated Immune Responses
72.0K
Overview
72.0K
01:18Surface Membrane Barriers
1.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.5K