肝移植后的认知功能障碍,精神疾病和功能衰退
Jessica M Ruck1, Emily C Murriel2, Nicole Fortune Hernandez1
1Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
概括
肝移植患者的长期认知功能通常会受到损害,影响生活质量. 这项研究发现,25%的受试者认知能力低于预期,这与更高的焦虑和抑郁率有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 神经科学是一个神经科学.
背景情况:
- 肝移植后认知障碍的长期了解很少.
- 它显著影响了接受者的生活质量.
研究的目的:
- 评估肝移植接受者的长期认知表现.
- 评估认知功能与心理健康结果之间的关联.
主要方法:
- 在2010年至2022年间移植的120名肝脏接受者的单中心队列研究.
- 基于电话的认知电池评估 > 移植后1年.
- 用于通过认知表现来比较抑郁症,焦虑症和自我报告功能的描述性统计数据.
主要成果:
- 25%的接受者表现出低于预期的认知能力,主要是口头学习和记忆.
- 46%的人报告有抑郁和/或焦虑症状.
- 与其他 (34-38%) 相比,高于预期的认知 (0%) 的人中,焦虑的发生率明显较低.
- 36%的人报告了日常功能受损,但与客观认知表现无关.
结论:
- 认知障碍在肝移植接受者中普遍存在>1年移植后.
- 低于预期的认知与增加的精神疾病相关.
- 对肝移植接受者来说,认知和心理健康的长度评估至关重要.
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