挪威先天性心脏缺陷的出生流行趋势 - 1994-2014年人口研究
Elisabeth Leirgul1, Tatiana Fomina2, Gottfried Greve1,3
1Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Acta paediatrica (Oslo, Norway : 1992)
|July 21, 2025
概括
从2004年至2014年,严重先天性心脏缺陷 (CHD) 的数量有所下降,主要是由于综合征病例较少,可能是由于妊娠终止. 然而,在挪威的整个研究期间, Septal 缺陷增加了.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 医学遗传学 医学遗传学
背景情况:
- 在欧洲,严重先天性心脏缺陷 (CHD) 的患病率呈现下降趋势.
- 这种下降可能受到胎儿异常妊娠终止的影响.
研究的目的:
- 在21年的时间里,分析挪威活产,死产和终止怀孕中心血管疾病患病率的趋势.
- 调查导致严重心脏病发病率变化的因素.
主要方法:
- 挪威医疗出生登记 (1994-2014) 的数据用于所有出生和终止.
- 链接注册表数据与CHD,心脏外缺陷和染色体异常的国家行政和临床注册表.
主要成果:
- 在1,261,952个总结结果 (每10,000人中149.3) 中,确定了18838名患有心血管疾病的个人.
- 严重的心脏病患病率在2004年之前增加,然后在2014年下降,综合性心脏病是这种下降的主要驱动因素.
- 在整个研究期间, Septal 缺陷的持续增加.
结论:
- 从2004年至2014年,严重心脏病发病率的下降主要归因于综合征病例的减少,这可能与终止妊娠有关.
- 终止怀孕似乎是影响严重心血管疾病观察到的趋势的一个重要因素.
- 在整个研究期间,观察到隔膜缺陷的增加趋势.
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