在COVID-19大流行期间,与不确定的QuantiFERON-TB Gold Plus测试结果相关的因素
Carla M Román-Montes1, Karla M Tamez-Torres1, Guillermo A Guaracha-Basañez2
1Infectious Diseases Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
PloS one
|July 21, 2025
概括
百分之十的QuantiFERON (QFT) 试验给出了不确定的结果,通常是由于米托基因反应低. 诸如严重的COVID-19和免疫抑制等因素与这些结果有关,建议推迟测试,直到患者的病情改善.
科学领域:
- 免疫学 免疫学 免疫学
- 传染病诊断 传染病诊断 传染病诊断
- 临床实验室科学 临床实验室科学
背景情况:
- 不确定的QuantiFERON (QFT) 结果在临床决策中带来了挑战,经常需要重复测试.
- 了解不确定的QFT结果的流行率和相关因素对于优化诊断策略至关重要.
研究的目的:
- 为了确定不确定的QuantiFERON (QFT) -Plus结果的流行率.
- 为了确定与不确定的QFT-Plus结果相关的临床和实验室因素.
主要方法:
- 一项回顾性研究,将未确定QFT结果的患者与确定的结果的患者进行比较.
- 分析了从2020年3月到2022年12月在墨西哥城的一家三级护理中心进行的4,557次QFT-Plus测试.
- 多变量回归分析以确定与不确定结果相关的因素.
主要成果:
- 10%的QFT-Plus测试导致不确定的读数,主要是由于低基因反应 (96%的病例).
- 与不确定的结果显著相关的因素包括严重的COVID-19,药物免疫抑制,严重的淋巴缺血,贫血和住院治疗 (非COVID-19).
- 确定和不确定结果的组之间没有发现年龄,性别或并发症的显著差异.
结论:
- 不确定的QFT-Plus结果的10%的患病率是显著的,特别是在COVID-19患者中.
- 不确定的结果与免疫抑制和严重疾病的指标有关.
- 推迟QFT-Plus测试,直到患者的临床状况有所改善,可能是建议提高测试可靠性.
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