开发和优化含有纳米细胞体的大提取物:成分比和超声波时间的影响
Mahmood Fahdil Saleem1, Salar Ali Ahmed1, Hamed Hassanzadeh2
1Department of Food Technology, Faculty of Agricultural Engineering Science, Salahaddin University-Erbil, Erbil, Iraq.
Chemistry & biodiversity
|July 21, 2025
概括
这项研究优化了植物体纳米载体 (PNCs) 与大提取物 (GE) 以增强抗菌特性. 在最佳条件下,可获得稳定的PNC,有效性提高,与GE无不良相互作用.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 植物体纳米载体 (PNCs) 提供了药物输送的潜力.
- 大提取物 (GE) 具有已知的抗微生物和抗氧化特性.
- 优化PNC配方对于最大化治疗效益至关重要.
研究的目的:
- 调查大提取物 (GE),胆固醇与莱西丁比率 (CLR) 和超声波持续时间对PNC物理化学和抗菌性质的影响.
- 为了确定稳定和有效的GE装载PNC的最佳配方参数.
- 评估GE和PNC组件之间的相互作用.
主要方法:
- GE度 (0%-3%),CLR (0-1) 和超声波持续时间 (10-30分钟) 的系统变化.
- PNC的表征包括粒子大小,泽塔潜力,封装效率,度,pH值和电导率.
- 里埃变换红外光谱法 (FT-IR) 用于分析组件相互作用.
- 抗微生物和抗氧化物质性评估.
- 在4周的储存期内进行稳定性评估.
主要成果:
- 超声波持续时间显著影响了粒子大小,泽塔潜力,封装效率,度和稳定性.
- GE度和CLR影响了pH和电导率.
- 装有GE的PNC表现出抗微生物和抗氧化活性,与更小的颗粒大小和增强的透率有关.
- 确定了最佳条件:3% GE,23,59分钟的超声波,CLR为0.52.
- FT-IR证实GE和PNC组件之间没有相互作用.
结论:
- 配方参数对GE载荷的PNC特性和稳定性具有关键影响.
- 优化的PNC显示出对抗微生物应用的巨大潜力.
- 开发的PNC是稳定的,没有与大提取物产生不良相互作用,验证了配方方法.
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