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Updated: Sep 14, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

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跨多个组织的多维拼接事件的张量分解,以识别与复杂特征相关的拼接介导风险基因

Yan Yan1, Rui Chen2,3, Hakmook Kang1

  • 1Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, United States of America.

PLoS computational biology
|July 21, 2025
PubMed
概括

这项研究引入了多组织剪接基因 (MTSG) 模型,以识别阿尔茨海默病和精神分裂症等复杂特征的剪接介导风险基因. MTSG有效地分析了多种组织的拼接变异,发现了与这些疾病的新型遗传联系.

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