在1型链上,人类P[28]轮状病毒VP8*蛋白与血型ABH抗原的特定结合
Yi Zheng1,2, Xiaoman Sun3, Yuting Li2
1State Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
PLoS pathogens
|July 21, 2025
概括
与大多数人类轮状病毒不同的是,A组轮状病毒P[28]菌株与特定的血型抗原结合. 这种广泛的结合,加上潜在的蝙蝠病毒重组,引发了对未来轮状病毒流行病的担忧.
科学领域:
- 病毒学 病毒学
- 结构生物学 结构生物学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- 轮状病毒 (RV) 是儿童胃肠炎的主要原因.
- 大多数人体RVs通过VP8*尖端蛋白通过糖甘血基组抗原 (HBGAs) 结合.
- 包括P[28]菌株在内的P[I]基因组不太了解,一些菌株与蝙蝠RVs有关.
研究的目的:
- 为了研究P[28]轮状病毒VP8*蛋白的HBGA结合特异性.
- 了解P[28] RVs对人类健康和潜在流行病的影响.
主要方法:
- 在X射线晶体学.
- 糖甘微阵列分析分析
- 生物层干涉测量是生物层的干涉测量.
- 特定地点的突变发生.
- 分子对接和动力学模拟.
主要成果:
- P[28]-VP8*与血液组A,B和H (O) 抗原结合,但仅在1型链上.
- P[28]-VP8* 不结合到易斯表位或粘素O-甘氨酸核.
- 这种广泛的结合与P[8],P[4]和P[6]等普遍存在的人类RV菌株有很大的不同.
结论:
- P[28]-VP8*的广泛HBGA结合与大多数人类RV不同.
- 与蝙蝠RV和P[28]结合的潜在重组表明未来P[I]基因组RV流行病的风险.
- 罗塔病毒监测应包括P[I]基因组病毒.
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