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相关概念视频

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

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复杂分子的选择性化:后期阶段的功能化.

Muyuan Wang1, Jonah Ruskin1, Joseph Marques1

  • 1Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

Chemical reviews
|July 21, 2025
PubMed
概括

晚期化使现有化合物能够有效地转化为有价值的化分子. 这一观点回顾了复杂分子 (包括药品) 的单原子修饰的关键策略.

科学领域:

  • 有机化学 有机化学
  • 药用化学 医学化学
  • 化学 的化学

背景情况:

  • 化反应有一个丰富的历史,跨越了160多年.
  • 将纳入生物活性分子提供了显著的优势.
  • 后期化在21世纪成为一种有效的策略.

研究的目的:

  • 提供关于后期化策略的全面概述.
  • 专注于复杂分子的单原子修饰.
  • 为了检查核友和电友源.

主要方法:

  • 对后期化技术的审查.
  • 对天然产品,类似产品和药品应用的方法分析.
  • 核性和电性化试剂的检查.

主要成果:

  • 几十年来开发了许多化试剂和方法.
  • 晚期化提供了一个比新合成更有效的途径.
  • 讨论的策略适用于复杂的分子结构.

结论:

  • 后期化是一个合理的,日益重要的领域.

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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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  • 提出的策略有助于有效合成化生物活性化合物.
  • 这一领域的持续研究有望在药物发现和开发方面取得进一步的进步.