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线性菌:在瘤免疫微环境中,它是放射治疗耐药性的关键调节剂

Jing Xia¹, Jing Jin², Shuang Dai³

¹Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Molecular aspects of medicine

|July 21, 2025

概括

线粒体,一个细胞过程,通过清除受损的线粒体,帮助癌细胞在放射治疗中存活. 这个过程也会影响瘤的微环境和免疫反应,影响治疗结果.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

癌症仍然是一个重大的全球健康挑战,放射治疗 (RT) 是主要的治疗方式.
放射电阻是RT疗效的显著限制,并且越来越多地认为线粒细胞活化是其中的一个因素.
瘤微环境 (TME) 在癌症进展和治疗反应中发挥着关键作用.

研究的目的:

审查线粒在调节放射治疗耐药性和TME的免疫格局中的双重作用.
为参与放射电阻的线粒调节通路提供机械洞察力.
探索菌体,新陈代谢重编程,免疫调节和对包括免疫疗法在内的各种癌症疗法的耐药性之间的相互作用.

主要方法:

文献综述总结了当前关于线粒及其在癌症中的作用的证据.
对关键的线粒体调节通路 (例如,PINK1/Parkin,BNIP3/NIX,FUNDC1) 进行分析,以应对辐射诱导的线粒体应激.
探索2型糖尿病 (T2DM) 对线粒细胞衰变,放射电阻和TME的影响.

主要成果:

线性可以通过清除受损的线粒体,维持新陈代谢平衡,减少氧化应激来增强癌细胞对RT的抗性.
线粒会影响TME内的免疫平衡,可能促进免疫抑制.
线粒细胞,代谢重编程和免疫调节的相互作用影响了对RT,ICI和CAR-T细胞疗法的耐药性.

结论:

线粒是适应性电阻和塑造TME免疫格局的关键因素.
准线粒菌通路是克服RT耐药性的潜在治疗策略.
了解线粒的作用,特别是在T2DM的背景下,对于开发个性化癌症治疗至关重要.

关键词:

糖尿病糖尿病糖尿病免疫调节免疫调节线粒细胞衰变 (mitophagy) 是一种神经衰变.抗辐射疗法耐药性抗辐射治疗耐药性瘤微环境 (TME) 是指瘤的微环境.

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