在痴呆症患者中使用潜在高风险的抗精神病药物:全国数据链接研究
Hieu T Le1, Edward C Y Lau1, Mohammad Afshar Ali2
1The University of Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Journal of the American Medical Directors Association
|July 21, 2025
概括
近90%使用抗精神病药物的澳大利亚痴呆症患者经历了高风险的使用,包括药物相互作用和长时间的处方. 这凸显了优化抗精神病药物在痴呆症护理中的使用所面临的挑战.
科学领域:
- 老年学是一门学科.
- 心理药理学 心理药理学
- 公共卫生 公共卫生
背景情况:
- 抗精神病药物经常被处方用于痴呆症 (BPSD) 的行为和心理症状.
- 然而,在老年人中,特别是那些患有痴呆症的人中,它们的使用与重大风险有关.
- 识别潜在高风险抗精神病药物使用模式对于提高患者安全至关重要.
研究的目的:
- 确定澳大利亚痴呆症患者中潜在高风险抗精神病药物的使用率.
- 确定与这些高风险处方模式相关的社会人口学因素.
主要方法:
- 一项回顾性横截面研究,利用2021年人口普查和制药福利计划的澳大利亚国家数据.
- 包括65岁以上痴呆症患者在2021年8月至10月期间购买抗精神病药物的个人.
- 评估了高风险使用的四个指标:药物相互作用,药物疾病相互作用 (中风,糖尿病),同时服用精神药物和长时间使用.
主要成果:
- 在22710名患有痴呆症的抗精神病药物使用者中,超过86%的人至少有一种高风险使用措施.
- 同时服用精神药物 (77.3%) 和药物相互作用 (31.1%) 是最常见的问题.
- 高龄 (≥75岁),高等教育和远程生活与较低的高风险使用概率有关,而多病症增加了使用概率.
结论:
- 潜在的高风险抗精神病药物的使用在澳大利亚痴呆症患者中非常普遍,这表明在实现高质量的使用方面存在重大挑战.
- 社会人口统计学因素影响高风险处方的可能性,特定的子组需要有针对性的干预措施.
- 需要进一步的研究来开发和实施战略,以优化这种脆弱人群的抗精神病药物处方.
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